Q&A: Have you had Candida? How did you get rid of it?
Question by Sury: Have you had Candida? How did you get rid of it?
How do you deal with systemic Candida? Has anyone actually been successful at curing it with the diet and pills, what the best way to get rid of systemic candida?
Best answer:
Answer by LadyBug
From Merriam-Webster on-line:
1capitalized: a genus of parasitic fungi that resemble yeasts, produce small amounts of mycelium, occur especially in the mouth, vagina, and intestinal tract where they are usually benign but can become pathogenic, and have been grouped with the imperfect fungi but are now often placed with the ascomycetes.
I’m not a doctor but I believe it can only be cured with prescription medication, some kind of antibiotic cream.
Add your own answer in the comments!
How do fungi become resistant to fluconazole?
Question by Tim S: How do fungi become resistant to fluconazole?
By fungi, I mean pathogenic fungi such as Candida albicans
Best answer:
Answer by Marilyn
The link below will take you to a discussion web site where you will also find Definition of Fluconazole Resistance, Prevention of Fluconazole-Resistant Candidiasis and Recommended Therapy for Fluconazole-Resistant Candidiasis.
Mechanisms for Fluconazole Resistance
Fluconazole exerts its action on the fungal membrane by inhibiting the synthesis of ergosterol, the predominant sterol in the fungal cell membrane[6]. Specifically, fluconazole blocks a step in the conversion of squalene to ergosterol by inhibiting the fungal cytochrome P-450 enzyme 14 alpha-demethylase (Figure 1)[6]. This inhibitory action prevents fungal cell replication and causes a build-up of lanosterol and other ergosterol precursors in the fungal cell membrane. The abnormalities in the fungal cell membrane eventually lead to cell death. The selective action of fluconazole for fungal cell membranes occurs because human cells use cholesterol, not ergosterol, for the synthesis of cell membranes. Resistance to fluconazole can develop as a result of an alteration in the target enzyme 14 alpha-demethylase (change in binding site or overexpression of the enzyme) or from enhanced drug efflux caused by plasma membrane transporters (Figure 2)[6,7,8,9,10]; many of the strains of fluconazole-resistant Candida species display multiple mechanisms of resistance[7].
Give your answer to this question below!
Categories: Candida Questions Tags: become, fluconazole, fungi, resistant
